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Several Common Refrigerants

2025-03-30
In daily work and study, we often come across various refrigerants labeled with codes starting with "R". Just like an ID number, each code represents a vivid "face" and "personality". As the essential "blood" for the operation of a refrigeration system, refrigerants require us practitioners to first understand and recognize these common "codes".
I. Refrigerants of Inorganic Compounds
R744: Carbon dioxide. Its chemical formula is CO₂, with a molecular weight of 44 and a boiling point of -78°C. It is a colorless and odorless gas at room temperature. It belongs to natural working substances, possessing good thermodynamic properties and environmental protection characteristics. In recent years, it has been reused and applied in the fields of heat pump water heaters and refrigeration air conditioners.

Several Common Refrigerants1743327198808

The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R717: Ammonia. Its chemical formula is NH₃, with a molecular weight of 17 and a boiling point of -33°C. It is a natural working substance, environmentally friendly, and has excellent thermodynamic properties. Ammonia has a large refrigeration capacity per unit volume and is inexpensive. It is widely used in large land-based cold storages and industrial installations. In devices using ammonia as a refrigerant, copper or copper alloys are generally not employed. The safety classification is B2 (toxicity classification is B, flammability is Class 2). In recent years, the NH₃/CO₂ cascade refrigeration system has been used as a substitute for the working substances in some low-temperature refrigeration cycle systems.
R718: Water. Its chemical formula is H₂O, with a molecular weight of 18 and a boiling point of 100°C. Water is used as a refrigerant in steam jet refrigeration and lithium bromide absorption refrigeration. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
II. Refrigerants of Hydrocarbons
R170: Ethane. Its chemical formula is C₂H₆, with a molecular weight of 30 and a boiling point of -89°C. The Ozone Depletion Potential (ODP) is 0. It is mainly used to replace R13 and R503, and also applied to the low-temperature part of the cascade refrigeration system. The safety classification is A3 (toxicity classification is A, flammability is Class 3).
R290: Propane. Its chemical formula is C₃H₈, with a molecular weight of 44.9 and a boiling point of -42.2°C. The Ozone Depletion Potential (ODP) is 0. It is used as a refrigerant to replace R22 and R502, and is compatible with the original system and lubricating oil. It is also used in two-stage compression refrigeration or the high-temperature part of the cascade refrigeration system. The safety classification is A3 (toxicity classification is A, flammability is Class 3).
R600a: Isobutane. Its chemical formula is CH(CH₃)₃, with a molecular weight of 58 and a boiling point of -12°C. The Ozone Depletion Potential (ODP) is 0. It is mainly used to replace the R12 refrigerant used in refrigeration equipment such as refrigerators and freezers. The safety classification is A3 (toxicity classification is A, flammability is Class 3).
R1270: Propylene. Its chemical formula is CH₂CH=CH₂, with a molecular weight of 42.08 and a boiling point of -48°C. The Ozone Depletion Potential (ODP) is 0. It is mainly used to replace R502 and R143a refrigerants, and is compatible with the original system and lubricating oil. It is also used in two-stage compression refrigeration or the high-temperature part of the cascade refrigeration system. The safety classification is A3 (toxicity classification is A, flammability is Class 3).
III. Refrigerants of Freons
R11: Trichlorofluoromethane. Its chemical formula is CCl₃F, with a molecular weight of 137.37 and a boiling point of 23.7°C.

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It is colorless, has an ether smell, is slightly soluble in water, and easily soluble in ethanol and ether, with good chemical stability. It was once mainly used as a refrigerant for large central air conditioners (centrifugal chiller units) and as a blowing agent for polyurethane (PU) foam plastics. Due to its strong destructive effect on the ozone layer, its production and use have been prohibited. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R12: Dichlorodifluoromethane. Its chemical formula is CCl₂F₂, with a molecular weight of 121 and a boiling point of -30°C. At room temperature, it is a colorless, odorless, and non-corrosive gas, with good thermal stability and chemical stability. As a refrigerant, it is widely used in the refrigeration and air conditioning fields such as refrigerators, freezers, and central air conditioning chiller units. However, due to its damage to the atmospheric ozone layer, its use has been restricted and banned. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R13: Chlorotrifluoromethane. Its chemical formula is CClF₃, with a molecular weight of 104.5 and a boiling point of -81.4°C. The Ozone Depletion Potential (ODP) is 1.0. Due to its damage to the atmospheric ozone layer, its use has been banned. It was once used as a low-temperature/ultra-low-temperature refrigerant, applied to ultra-low-temperature freezers, ultra-low-temperature test chambers, etc., and served as the refrigerant for the low-temperature part in the cascade refrigeration device at -80°C to -120°C. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R22: Chlorodifluoromethane. Its chemical formula is CHClF₂, with a molecular weight of 86.47 and a boiling point of -41°C. At room temperature, it is a colorless and nearly odorless gas. It has high chemical stability and thermal stability, and its thermodynamic properties are similar to those of ammonia. It is safer and more reliable than ammonia refrigerant in use. It is one of the most commonly used Freon refrigerants and is widely adopted in frozen and refrigerated display cabinets, household air conditioners, and low-temperature refrigerators. In 1990, R22 was identified as a transitional substance to replace CFCs. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R23: Trifluoromethane. Its chemical formula is CHF₃, with a molecular weight of 70 and a boiling point of -82°C. The Ozone Depletion Potential (ODP) is 0. It is an environmentally friendly refrigerant, a substitute for R13 and R503, and is used in ultra-low-temperature and deep-freezing equipment, mostly in the low-temperature stage of cascade refrigeration. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R32: Difluoromethane. Its chemical formula is CH₂F₂, with a molecular weight of 52 and a boiling point of -52°C. It is colorless and odorless, a gas at room temperature, and a colorless transparent liquid under its own pressure. It is easily soluble in oil and difficult to dissolve in water. It is a refrigerant with zero ozone depletion potential and a substitute for R22. It is non-toxic, flammable and explosive, with a relatively high risk in use. The safety classification is A2 (toxicity classification is A, flammability is Class 2). The thermodynamic properties of R32 are very close to those of R410A. Generally, for the same system, after replacing the refrigerant and making the necessary matching, its working pressure is slightly higher than that of the R410A system, and the exhaust temperature is higher. If the compressor displacement is the same, the cooling capacity of the system using R32 will increase by about 12%, and the COP will increase by about 5%.
R123: Dichlorotrifluoroethane. Its chemical formula is CHCl₂CF₃, with a molecular weight of 153 and a boiling point of 27.85°C. The Ozone Depletion Potential (ODP) is 0.02. It is an HCFC-type refrigerant that replaces R11. It is mainly used in central air conditioners/centrifugal chiller units. The safety classification is B1 (toxicity classification is B, flammability is Class 1).
R134a: Tetrafluoroethane. Its chemical formula is CH₂FCF₃, with a molecular weight of 102 and a boiling point of -26°C. It is one of the main refrigerants to replace R12, and is commonly used in automotive air conditioners, commercial and industrial refrigeration systems. It can also be used to formulate other mixed refrigerants, such as R404A and R407C. The safety classification is A1 (toxicity classification is A, flammability is Class 1).
R142b: Chlorodifluoroethane. Its chemical formula is CH₃CClF₂, with a molecular weight of 100.5 and a boiling point of -10°C. At room temperature, it is a colorless gas with a slight aromatic smell, easily soluble in oil and difficult to dissolve in water. It is mainly used as an air-cooled air conditioner in high-temperature environments and a refrigeration system for cooling. The safety classification is A2 (toxicity classification is A, flammability is Class 2).
R152a: Difluoroethane. Its chemical formula is CH₃CHF₂, with a molecular weight of 66.1 and a boiling point of -25°C. The Ozone Depletion Potential (ODP) is 0. It is mainly used as a refrigerant, blowing agent, aerosol, and cleaning agent, and usually forms a mixed working substance with other refrigerants. The safety classification is A2 (toxicity classification is A, flammability is Class 2).
IV. Non-azeotropic Solution Refrigerants
R402A: The mass composition percentage is R125/290/22 (60/2/38). The average molecular weight is 101.6, the bubble point is -49.2°C, and the dew point is -47°C.
R402B: The mass composition percentage is R125/290/22 (38/2/60). The average molecular weight is 94.7, the bubble point is -47.2°C, and the dew point is -44.9°C. They are used to replace R502 and are mainly used in commercial refrigeration equipment and some transportation refrigeration facilities. The safety classification is A1/A1.
R404A: The mass composition percentage is R125/143a/134a (44/52/4). The average molecular weight is 97.6, the bubble point is -46.6°C, and the dew point is -45.8°C. At normal temperature and pressure, it is a colorless gas, and it is a compressed liquefied gas when stored in a steel cylinder. Its ODP is 0, and it is an environmentally friendly refrigerant that does not damage the atmospheric ozone layer. It is used to replace R22 and R502 and applied in medium and low-temperature refrigeration systems. The saturated pressure of R404 is higher and the gas density is larger than that of R22. Therefore, the sealing materials of valves, the design pressure of pressure vessels, the set values of safety valves and fusible plugs, and the set values of high and low-pressure switches in the R404 refrigeration device are different from those in the R22 system. The safety classification is A1/A1.
R407C: The mass composition percentage is R32/125/134a (23/25/52).

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The average molecular weight is 86, the bubble point is -43.8°C, and the dew point is -36.7°C. At normal temperature and pressure, it is a colorless gas, and it is a compressed liquefied gas when stored in a steel cylinder. Its ODP is 0, and it is an environmentally friendly refrigerant that does not damage the atmospheric ozone layer. It is mainly used to replace R22 and is used in household air conditioners and small and medium-sized central air conditioners. The safety classification is A1/A1.
R408A: The mass composition percentage is R125/143a/22 (7/46/47). The average molecular weight is 87, the bubble point is -45.5°C, and the dew point is -45°C. At room temperature, it is a colorless gas, and the Ozone Depletion Potential (ODP) is 0.016. It is mainly used to replace R502. The safety classification is A1/A1.
R409A: The mass composition percentage is R22/124/142b (7/46/47). The average molecular weight is 97.4, the bubble point is -35.4°C, and the dew point is -27.5°C. At room temperature, it is a colorless gas. The boiling point is -34.5°C, and the Ozone Depletion Potential (ODP) is 0.039. It is a substitute for R12. The safety classification is A1/A1.
R410A: The mass composition percentage is R32/125 (50/50). The average molecular weight is 72.6, the bubble point is -51.6°C, and the dew point is -51.5°C. At normal temperature and pressure, it is a colorless gas, and it is a compressed liquefied gas when stored in a steel cylinder. Its ODP is 0, and it is an environmentally friendly refrigerant that does not damage the atmospheric ozone layer. It is mainly used to replace R22 and R502 and is used in household air conditioners, small commercial air conditioners, and household central air conditioners. When charging R410A, the system must be evacuated to a vacuum, and no trace of air or moisture can be mixed in; otherwise, the working efficiency will be greatly reduced. The safety classification is A1/A1.
R417A: The mass composition percentage is R125/134a/600 (46.6/50/3.4). The average molecular weight is 106.7, the bubble point is -41.2°C, and the dew point is -40.1°C. At normal temperature and pressure, it is a colorless gas, and it is a compressed liquefied gas when stored in a steel cylinder. Its ODP is 0, and it is an environmentally friendly refrigerant that does not damage the atmospheric ozone layer.

Several Common Refrigerants1743327198762

It is mainly used to replace R22 and is used in heat pumps and air conditioners.
V. Azeotropic Solution Refrigerants
R502: The mass composition percentage is R22/115 (48.8/51.2), the average molecular weight is 112, and the boiling point is -45°C. It is mainly used as a low-temperature refrigerant and can be used as a refrigerant for food display, food storage, refrigeration, ice cream machines, low-temperature refrigerators, and low-temperature refrigeration compressors. Due to the presence of substances that damage the ozone layer, its use has been restricted and banned. The safety classification is A1.
R503: The mass composition percentage is R23/13 (40.1/59.9), the average molecular weight is 87.5, and the boiling point is -88°C. It is mainly used in ultra-low-temperature refrigeration equipment such as low-temperature test chambers and freeze-drying equipment. Due to the presence of substances that damage the ozone layer, its use has been restricted and banned. The safety classification is A1.
R507: The mass composition percentage is R125/143a (50/50), the average molecular weight is 98.9, and the boiling point is -46.7°C. At normal temperature and pressure, it is a colorless gas, and it is a compressed liquefied gas when stored in a steel cylinder. Its ODP is 0, and it is an environmentally friendly refrigerant that does not damage the atmospheric ozone layer. It is mainly used to replace R22 and R502 and is used in medium and low-temperature refrigeration systems. The safety classification is A1.
R508A: The mass composition percentage is R23/116 (39/61), the average molecular weight is 100.1, and the boiling point is -86°C. (R508B: The mass composition percentage is R23/116 (46/54), the average molecular weight is 95.41, and the boiling point is -88.3°C.) At normal temperature and pressure, it is a colorless gas, and it is a compressed liquefied gas when stored in a steel cylinder. Its ODP is 0, and it is an environmentally friendly refrigerant that does not damage the atmospheric ozone layer. It is mainly used to replace R13, R23, and R503 and is used in ultra-low-temperature refrigeration systems, such as medical refrigeration and scientific research refrigeration. The safety classification is A1.
There are many types of refrigerants. The ones mentioned above are just some that we often encounter in our work. Since refrigerants with different properties are suitable for different refrigeration devices, and with the research and development of green and environmentally friendly refrigerants and the emergence of new refrigerants, detailed consultation and understanding are needed when using them. In addition, specific usage should be carefully examined according to the actual situation.
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